Clot firmness testing

>>Clot firmness testing
Clot firmness testing2018-10-09T17:45:26+00:00

Our expertise in viscoelastometry

The enicor team is led by developers and specialists in the field of viscoelastometry and platelet function analysis.


Blood coagulation is a dynamic process leading to the formation of a blood clot

The ultimate result of the clotting process is the formation of the blood clot, which leads to the closure of the vascular injury and the cessation of bleeding. The blood clot consists of a three dimensional network of polymerized fibrin and activated platelets. The blood clot is formed by thrombin, which is activated through the coagulation cascade, a series of enzymes, which serially activate each other. When free thrombin is formed, fibrinogen is split into fibrin, plateles become activated and the blood clot is formed. Subsequently the blood clot may be stable, or might be dissoluted by fibrinolysis, the part of the coagulation system that limits blood clots in space and time.


Clot firmness testing

Several methods are being used to measure blood clot firmness in whole blood. These methods are usually summarized with the term “viscoelastic methods”. The most widely used technique is thrombelastography / thrombelastometry, which was invented by Hartert almost 70 years ago.

By continuously recording blood clot firmness thrombelastography allows the detection of various changes of the coagulation system, such as a delayed initiation of clotting, a reduced clot formation or increased fibrinolysis.

Therefore today thrombelastography is widely used for the management of acute bleeding complications and the selection of the most appropriate therapy to acute hemostasis disorders.

(1) Rossaint R et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100.
(2) Kozek-Langenecker SA et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2013 Jun;30(6):270-382.
(3) American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management. Anesthesiology. 2015 Feb;122(2):241-75.
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